"We'll sit outside the port's gate from Saturday afternoon to Sunday evening continuously to block the trucks carrying NATO supplies" to Afghanistan, AFP quoted opposition leader Imran Khan, who called for the sit-in, as saying on Saturday.
Most of the equipment needed by the US-led foreign forces in Afghanistan is dispatched to Karachi port in southern Pakistan and then carried by trucks to the landlocked country.
"We'll be protesting against the drone strikes till our people are truly liberated from the clutches of monsters," Khan went on to say.
Khan, the leader of Tehreek-e-Insaf, accused the Pakistani government of giving full liberty to its "American masters to kill Pakistanis at will."
Last Saturday, Pakistani lawmakers demanded an immediate end to the US drone strikes. They warned that Islamabad would block the NATO supplies transport route from Pakistan to Afghanistan if the attacks are repeated.
However, the drone attacks continued during the past week, killing at least 17 people in North Waziristan tribal district.
Washington claims the airstrikes target militants, but most of the attacks result in civilian casualties.
Pakistani officials believe that the militants have shifted their operations from Waziristan and the Orakzai Agency to the Kurram Agency.
The aerial assaults, initiated by former US president George W. Bush, have escalated under President Barack Obama.
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