Ayatollah Khamenei made the remarks in a meeting with members of a committee responsible to commemorate 15,000 combatants of Khomeini Shahr on December 16 but the remarks of the leader were released on Wednesday night.
The Leader emphasized the importance of the spirit of resistance against evil and perseverance in the right path.
"If the spirit of resistance does not exist in a country, it will be destroyed; that is to say that this society will lose its honor dignity and independence," he underlined.
The Leader also emphasized the need for maintaining the spirit of defending the right and striving for God’s sake.
In relevant remarks last month, Iranian President Hassan Rouhani underlined that given the US stubbornness in opposition to the removal of the sanctions against Iran, his country has no way but resistance against Washington.
"We are in sanctions conditions and it is not our fault and these conditions have been created with the provocation of the Zionists and the reactionary regimes in the region," Rouhani said in Tehran.
"In such conditions, we do not have any way but resistance against those that have imposed the sanctions. Meantime, we have not closed the doors to talks," he added.
President Rouhani stressed that once the US removes the "terrorist unfair" sanctions, the two countries' high-ranking officials could meet within the framework of the Group 5+1.
He said when he was in New York for a UN General Assembly meeting, he had told the European interlocutors that he would meet the US president immediately after and only when Trump removed the sanctions on Iran.