The Britain-based Syrian Observatory for Human Rights said the aerial attack hit the village of al-Dablan, located about 20 kilometers (13 miles) southeast of Mayadin town, early on Wednesday.
The deadly airstrike is the second in 48 hours that the US-led coalition has conducted in Dayr al-Zawr province.
On Monday, dozens of people lost their lives when a string of coalition strikes targeted a jail run by ISIS extremists in Mayadin, located some 45 kilometers (28 miles) southeast of the provincial capital of Dayr al-Zawr.
The observatory said the aerial assaults left 42 prisoners and 15 ISIS terrorists dead.
The US-led coalition has been conducting airstrikes against what are said to be ISIS targets inside Syria since September 2014 without any authorization from the Damascus government or a UN mandate.
The military alliance has repeatedly been accused of targeting and killing civilians. It has also been largely incapable of fulfilling its declared aim of destroying ISIS.
Syria has been fighting different foreign-sponsored militant and terrorist groups since March 2011. UN Special Envoy for Syria Staffan de Mistura estimated last August that more than 400,000 people had been killed in the crisis until then.
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28 June 2017 - 12:08
News ID: 839256
(AhlulBayt News Agency) - A so-called monitoring group says at least 30 civilians have been killed and dozens more sustained injuries when the US-led coalition purportedly fighting the ISIS Takfiri terrorist group carried out an airstrike in Syria's troubled eastern province of Dayr al-Zawr.